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利伐沙班雜質(zhì)列表及結(jié)構(gòu)式見附件。

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利伐沙班雜質(zhì)1

2,2'-((2R,2'R)-((4-(3-oxomorpholino)phenyl)azanediyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione)

利伐沙班雜質(zhì)2

1,3-bis(4-(3-oxomorpholino)phenyl)urea

利伐沙班雜質(zhì)3

N1,N2-bis(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)phthalamide

利伐沙班雜質(zhì)4

(S)-N1-methyl-N2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)phthalamide

利伐沙班雜質(zhì)5

(S)-1-(5-chlorothiophene-2-carboxamido)-3-(N-(4-(3-oxomorpholino)phenyl)acetamido)propan-2-yl acetate

利伐沙班雜質(zhì)6

(S)-2,5-dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-3-carboxamide

利伐沙班雜質(zhì)7

(R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)8

(S)-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)9

(S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)10

1,3-bis(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)urea

利伐沙班雜質(zhì)11

(S)-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)acetamide

利伐沙班雜質(zhì)12

N1-(((R)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)-N2-(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)phthalamide

利伐沙班雜質(zhì)13

(R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)14

5-chloro-N-(1-hydroxy-2-((4-(3-oxomorpholino)phenyl)amino)ethyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)15

(S)-5-chloro-N-((3-(4-(2-hydroxy-N-(2-hydroxyethyl)acetamido)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)16

5-chloro-N-(((5S)-3-(4-(3-hydroxy-5-oxomorpholino)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)17

5-chloro-N-(4-((S)-5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-oxo-2-((((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)amino)ethoxy)ethyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)18

(S)-5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(3-(methylamino)-3-oxopropoxy)ethyl)thiophene-2-carboxamide

利伐沙班雜質(zhì)19

5-chloro-N-(3-(5-chlorothiophene-2-carboxamido)-2-hydroxypropyl)-N-(4-(3-oxomorpholino)phenyl)thiophene-2-carboxamide