靈菌紅素Prodigiosin/靈菌紅素通過活化半胱天冬酶誘導(dǎo)人原發(fā)性癌細(xì)胞的凋亡
Prodigiosin
Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably, Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant in 2007. The mode of action of prodigiosin has recently received considerable attention as an inducer of apoptosis in human primary cancer cells via caspase activation. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway, and of NAG-1activation by acting on glycogen synthase kinase-3beta.
CAS # : 82-89-3
Molecular Formula : C20H25N3O
Molecular Weight : 323.4
Source : Serratia marcescens MST-AS5330
Appearance : Dark red solid
Purity : > 95%
Long Term Storage : -20°C
Solubility : Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
References
1. Seeing red: The story of prodigiosin. Bennett J.W. & Bentley R., Adv. Appl. Microbiol. 2000, 47, 1.
2. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Campas C. et
al., Leukemia 2003, 17, 746.
3. Prodigiosin: a novel family of immunosuppressants with anti-cancer activity. Pandey R. et al., Indian J.
Biochem. Biophys. 2007, 44, 295.
4. The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factorbeta
receptor pathway. Soto-Cerrato V. et al., Biochem Pharmacol. 2007, 74, 1340.
5. Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human
breast cancer cells. Soto-Cerrato V. et al., Mol. Cancer Ther. 2007, 6, 362.
6. Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7
MR) cell line. Monge M. et al., Invest. New Drugs 2007, 25, 21.
靈菌紅素 CAS 號. 82-89-3
靈菌紅素是由若干種細(xì)菌特別是粘質(zhì)沙雷菌產(chǎn)生的一種紅色吡咯色素。靈菌紅素有廣譜的生物學(xué)活性，抗真菌、腫瘤細(xì)胞系和瘧疾。2007年發(fā)現(xiàn)它是一種免疫抑制劑。近來靈菌紅素的作用方式受到大量的關(guān)注，作為一種誘導(dǎo)劑通過活化半胱天冬酶誘導(dǎo)人原發(fā)性癌細(xì)胞的凋亡，并通過轉(zhuǎn)化β生長因子受體途徑誘導(dǎo)p21WAF1/CIP1表達(dá)，通過作用3β糖原合成酶激酶活化N-乙酰-β-葡萄糖苷酶。
