Background:  NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain （NICD） it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy （CADASIL） （swissprot）.

 

Specificity :     · anti-NOTCH3 is a rabbit polyclonal antibody unconjugated

                 · specific for NOTCH3 of human, mo, rat, horse 

                 · epitope mapping near the amino terminus of NOTCH3 of human, mo,

rat, horse origin

                 ·use for western blotting, elisa, immunoprecipitation and 

· Protein A affinity chromatography purification, purity :>95%

· Isotype: IgG

                 · mol wt:255kDa

 

Application :   ·Western blotting 1:100-500

                 ·Immunohistochemistry 1:100-500

                 ·ELISA 1:500-1000

 · Optimal working dilutions must be determined by the end user.

 

 

Important Note: This product as supplied is intended for research use only, not for use in

human, therapeutic or diagnostic applications.