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英文名稱(chēng) Anti-14-3-3 Tau/FITC
中文名稱(chēng) FITC標(biāo)記的14-3-3τ蛋白抗體
別 名 14 3 3 protein T cell; 14 3 3 protein tau; 14 3 3 protein theta; 14 3 3 tau; 14 3 3 theta; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 1433T_HUMAN; 1C5; HS1; KCIP1; Protein HS1; Protein kinase C inhibitor protein 1; Protein tau; tyr3/trp5 monooxygenase activation protein, theta; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide; YWHAQ.
說(shuō) 明 書(shū) 100ug
研究領(lǐng)域 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 細(xì)胞類(lèi)型標(biāo)志物
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human 14-3-3 Tau
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
FITC標(biāo)記的14-3-3τ蛋白抗體保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FITC標(biāo)記的14-3-3τ蛋白抗體產(chǎn)品介紹 background:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
Subcellular Location:
Cytoplasm. In neurons, axonally transported to the nerve terminals.
Tissue Specificity:
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Post-translational modifications:
Ser-232 is probably phosphorylated by CK1.
Similarity:
Belongs to the 14-3-3 family.
Database links:
Entrez Gene: 10971 Human
Entrez Gene: 768311 Cow
Entrez Gene: 22630 Mouse
Entrez Gene: 25577 Rat
Omim: 609009 Human
SwissProt: Q3SZI4 Cow
SwissProt: P27348 Human
SwissProt: P68254 Mouse
SwissProt: P68255 Rat
Unigene: 74405 Human
Unigene: 289630 Mouse
Unigene: 2502 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.