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英文名稱 Anti-8-OHdG/FITC
中文名稱 FITC標(biāo)記的8-羥基脫氧鳥苷抗體
別 名 8 Hydroxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8 hydroxy 2’ deoxyguanosine; 8 hydroxyguanine; 8 hydroxyguanosine; 8 OHG; 8-OHG; 8OG; 8OHdG; 8OHG;   
說 明 書 100ug  
產(chǎn)品類型 藥物與化合物抗體 
研究領(lǐng)域 腫瘤  染色質(zhì)和核信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) 8-OHdG
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 0.283kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated to 8-OHdG
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

藥物 化合物抗體
8-羥基脫氧鳥苷是活性氧自由基(ROS)引起DNA氧化損傷修飾產(chǎn)物之一,其生成原因很多,主要是電離輻射、化學(xué)致癌物代謝活化及細胞正常新陳代謝過程產(chǎn)生大量ROS直接攻擊DNA中的*(dG),使脫氧鳥苷氧化為8-OHdG。目前已成為DNA氧化損傷中zui常采用的生物標(biāo)志物.