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聯(lián)系人:李經(jīng)理 (經(jīng)理)

技術文章

Anti-CYP2D6 抗體說明書

閱讀:231發(fā)布時間:2012-9-13

 Anti-CYP2D6 抗體說明書,

 
Cat. Number:  Rs-1027R  
Quantity size:  0.1ml (dilute with pH 7.4    0.01 M PBS or diluent of antibody)
 
Background: commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).

 
Also known as: Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450 DB1; P450C2D; P450DB1; Xenobiotic monooxygenase.
 
Specificity:      · anti- CYP2D6 is a rabbit monoclonal antibody unconjugated
 · specific for CYP2D6 of human, rat,mouse and chicken  
 · epitope mapping near the C terminus of CYP2D6 of human, rat mouse
and chicken
· human, rat, mouse and chicken cross reacted    
· use for western blotting, elisa, immunoprecipitation    
   and immunohistochemistry
· Protein A affinity chromatography purification, purity :>95%
· Isotype: IgG   · mol wt: 48kDa
 
Application:     · Western blotting: 1:100-500
· Immunohistochemistry: 1:100-500
· ELISA: 1:500-1000
· Optimal working dilutions must be determined by the end user.
 
Storage:   Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºC.
 
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 

 


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