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當前位置：珀金埃爾默醫(yī)學診斷產(chǎn)品（上海）有限公司>>>>Ketanserin, (R41468), [Benzoyleneurea-3H], 250 µCi (9.25MBq)

Ketanserin, (R41468), [Benzoyleneurea-3H], 250 µCi (9.25MBq)

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產(chǎn)品簡介

Ketanserin (Sufrexal; R41468), tritiated on the benzoyleneurea group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2A receptors. This is a replacement for NET791250UC.

詳細介紹

Ketanserin is used as a radioligａnd for serotonin 5-HT2 serotonin receptors. Ketanserin is used clnical as an antihypertensive agent.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References:

1. Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Kyoji Sekiguchi, Yasushi Ikarashi, Yoshio Kase, Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, In Journal of Ethnopharmacology, Volume 166, 2015, Pages 23-30.

2. Lydia Schiller, Markus Donix, Monika J?hkel, Jochen Oehler, Serotonin 1A and 2A receptor densities, neurochemical and behavioural characteristics in two closely related mice strains after long-term isolation, In Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 30, Issue 3, 2006, Pages 492-503.

3. Daniel Hoyer, Günter Engel, Hans O. Kalkman, Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligａnd binding studies with [3H]5-HT, [3H]8-OH-DPAT, (?)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin, In European Journal of Pharmacology, Volume 118, Issues 1–2, 1985, Pages 13-23.

規(guī)格

檢測技術(shù) Radiometric
濃度 1.0 - 10 mCi/mL
檢測方法 Radiometric
實驗類型 In vitro
標簽位置 Specifically Labeled
分子量 431.9
產(chǎn)品品牌名稱 NEN Radiochemicals
放射性核素 3H
受體類型 5-Hydroxytryptamine
運輸條件 干冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域 CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
產(chǎn)品尺寸 250 µCi

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