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α-MSH, Nle4, D-Phe7, [125I], 10µCi

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更新時間：2022-10-15 14:16:39瀏覽次數(shù)：51次

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珀金埃爾默醫(yī)學診斷產(chǎn)品（上海）有限公司

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產(chǎn)品簡介

α-Melanocyte-stimulating hormone (α-MSH), labeled with 125I. α-MSH is an endogenous hormone that acts as a non-selective full agonist of melanocortin receptors MC1, MC3, MC4, and MC5.

詳細介紹

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX352:

Conde-Frieboes, K., Th?gersen, H., Lau, J.F., Sensfuss, U., Hansen, T.K., Christensen, L., Spetzler, J., Olsen, H.B., Nilsson, C., Raun, K., Dahl, K., Hansen, B.S., Wulff, B.S. (2012), Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues. J Med Chem, 55 (5): 1969-1977.
Vagner, J., Handl, H.L., Gillies, R.J., Hruby, V.J. (2004), Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett, 14 (1): 211-215.

規(guī)格

檢測方法	Radiometric
新鮮的很多天	Third Monday of each month
標簽位置	Nominally Labeled
產(chǎn)品品牌名稱	NEN Radiolabeled Ligands
放射性同位素	I-125
放射性核素	¹²⁵I
受體類型	Melanocortin
運輸條件	干冰
特殊訂購信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域	CNS & Neurologic, Pain, Inflammation, Metabolic Disorders
產(chǎn)品尺寸	10 µCi