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Citalopram, [N-Methyl-3H]-, 50µCi (1.85MBq)

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產(chǎn)品簡介

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).

詳細介紹

Citalopram (Celexa, Cipramil) is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter (SERT, 5-HTT). Citalopram is used to treat panic disorder as well as obsessive-compulsive disorder.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1039:

Pamela R. Tsuruda, Joey Yung, William J. Martin, Ray Chang, Ngoc Mai, Jacqueline A.M. Smith, Influence of ligａnd binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters, In Journal of Pharmacological and Toxicological Methods, Volume 61, Issue 2, 2010, Pages 192-204.
Assié, M.-B. and Koek, W. [3H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT1A and non-5-HT1A receptors. British Journal of Pharmacology, Volume 130, 2000, Pages 1348–1352.

規(guī)格

檢測方法	Radiometric
標簽位置	Specifically Labeled
產(chǎn)品品牌名稱	NEN Radiochemicals
放射性同位素	H-3
放射性核素	³H
受體類型	Serotonin
運輸條件	干冰
特殊訂購信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域	CNS & Neurologic
產(chǎn)品尺寸	50 µCi