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詳細(xì)介紹
C8柱更大化效率與通量
CORTECS C8柱是CORTECS家族的另一新成員。與典型C18柱相比，CORTECS C8柱的疏水保留性更低，因此有利于強(qiáng)疏水性化合物的分離與分析。CORTECS C8柱還適用于將常規(guī)C8柱HPLC方法轉(zhuǎn)換/升級(jí)到更耐用的色譜柱技術(shù)。
CORTECS C8柱的優(yōu)勢：
將常規(guī)C8柱HPLC方法轉(zhuǎn)換至更為穩(wěn)定耐用的色譜柱技術(shù)
與典型C18柱相比，疏水保留性較低
低pH條件下鍵合相穩(wěn)定
兼容LC-MS
使用CORTECS C8 色譜柱根據(jù)USP方法分析中的雜質(zhì)
政府監(jiān)管機(jī)構(gòu)要求制藥公司必須根據(jù)美國藥典(USP)中的標(biāo)準(zhǔn)對(duì)藥物 制劑化合物進(jìn)行分析。USP方法通常采用內(nèi)徑4.6 mm、填充顆粒直徑 在3 µm以上的大尺寸色譜柱，使得分析時(shí)間非常長，且流動(dòng)相消耗 量非常大。 要想縮短運(yùn)行時(shí)間，進(jìn)而縮短周轉(zhuǎn)時(shí)間和減少溶劑消耗量，方法之 一就是將原始USP方法轉(zhuǎn)換至填充有高柱效實(shí)心核顆粒的小尺寸色譜 柱1 ，而CORTECS色譜柱正是進(jìn)行這種方法革新的理想之選。該系列色 譜柱采用了含有多種鍵合配體基團(tuán)的實(shí)心核顆粒，苯基和C8 填料是 CORTECS產(chǎn)品系列的成員。這些新的填料可分別用于革新USP指 導(dǎo)原則中使用L11和L7色譜柱的方法，能夠在不影響柱效的前提下縮 短運(yùn)行時(shí)間。 在本應(yīng)用中，我們將分析中雜質(zhì)的USP方法分別轉(zhuǎn)換至三種 不同的色譜柱。方法轉(zhuǎn)換過程選用了3種不同粒徑的色譜柱，并以 USP通用章節(jié)<621>作為指導(dǎo)。
| 品名 | 編號(hào) |
| CORTECS HILIC Column, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg | 176003286 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 50 mm, 3/pkg | 176003810 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 100 mm, 3/pkg | 176003812 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 150 mm, 3/pkg | 176003813 |
| CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 30 mm, 3/pkg | 176003834 |
| CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 50 mm, 3/pkg | 176003835 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 30 mm, 1/pkg | 186008358 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 50 mm, 1/pkg | 186008359 |
| CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 50 mm, 1/pkg | 186008409 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 75 mm, 1/pkg | 186008350 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 100 mm, 1/pkg | 186008351 |
| CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 30 mm, 1/pkg | 186008408 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 150 mm, 1/pkg | 186008352 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 100 mm, 3/pkg | 176003807 |
| CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 75 mm, 1/pkg | 186008410 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 150 mm, 3/pkg | 176003808 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 30 mm, 3/pkg | 176003809 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 30 mm, 3/pkg | 176003804 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 50 mm, 3/pkg | 176003805 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 75 mm, 3/pkg | 176003806 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 50 mm, 1/pkg | 186008349 |
| CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 30 mm, 1/pkg | 186008348 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 150 mm, 1/pkg | 186008362 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 100 mm, 1/pkg | 186008361 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 150 mm, 3/pkg | 176003818 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 30 mm, 3/pkg | 186008403 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 50 mm, 3/pkg | 186008404 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 30 mm, 3/pkg | 176003814 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 50 mm, 3/pkg | 176003815 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 75 mm, 3/pkg | 176003816 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 100 mm, 3/pkg | 176003817 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg | 176003811 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 30 mm, 3/pkg | 186008353 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 100 mm, 3/pkg | 186008356 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 150 mm, 3/pkg | 186008357 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 100 mm, 1/pkg | 186008371 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 150 mm, 1/pkg | 186008372 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 100 mm, 3/pkg | 186008406 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 75 mm, 3/pkg | 186008405 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 75 mm, 1/pkg | 186008370 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 150 mm, 3/pkg | 186008407 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 50 mm, 3/pkg | 186008414 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 75 mm, 3/pkg | 186008415 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 30 mm, 3/pkg | 186008413 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 30 mm, 1/pkg | 186008368 |
| CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 50 mm, 1/pkg | 186008369 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 150 mm, 3/pkg | 186008417 |
| CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 100 mm, 3/pkg | 186008416 |
| CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 75 mm, 1/pkg | 186008360 |
| CORTECS C8 VanGuard Cartridge, 90?, 2.7 µm, 2.1 mm X 5 mm, 3/pkg | 186008421 |
| CORTECS C8 VanGuard Cartridge, 90?, 2.7 µm, 3.9 mm X 5 mm, 3/pkg | 186008422 |
| CORTECS C8 VanGuard Pre-column, 90?, 1.6 µm, 2.1 mm X 5 mm, 3/pkg | 186008423 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 50 mm, 3/pkg | 186008354 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 75 mm, 3/pkg | 186008355 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 75 mm, 3/pkg | 186008375 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 100 mm, 3/pkg | 186008376 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 150 mm, 3/pkg | 186008377 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 30 mm, 3/pkg | 186008373 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 50 mm, 3/pkg | 186008374 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 100 mm, 3/pkg | 186008366 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 150 mm, 3/pkg | 186008367 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 50 mm, 3/pkg | 186008364 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg | 186008365 |
| CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 30 mm, 3/pkg | 186008363 |
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