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廣泛的選擇性，即使裝填在低分散性的柱體內(nèi)，*的分離效果、穩(wěn)定性。

詳細(xì)介紹

XSelect HSS C18 SB 柱是超高效通用性C18色譜柱，用于提供對(duì)堿性分析物的優(yōu)異峰形、提高保留(相對(duì)于BEH C18柱)，以及在低pH條件下的極長(zhǎng)柱壽命。HSS C18柱所表現(xiàn)出的選擇性與保留性與大多數(shù)現(xiàn)代全封端的硅膠C18色譜柱色譜行為較為相近。

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Development and validation of new RP-HPLC method for the determination of gliclazide in tablet dosage form

A new sensitive and economic analytical method for the analysis of gliclazide in tablet dosage form was developed and validated using commercial HPLC instrument with modern ultra-performance liquid chromatography column. Samples were analysed using Agilent 1100 Series RP-HPLC equipped with a binary pump and auto injector. Samples were injected into Xselect HSS C18 XP column (2.1 × 100 mm, 2.5 μm), 2.5 μm) and the phase consisted of triethylamine buffer 0.3% (pH = 3 adjusted using phosphoric acid) and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.4 mL/min and the DAD detector was used for the detection and the wavelength was 229 nm. The method was validated according to ICH guidelines. The retention time for gliclazide peak was 3.437 ± 0.41 min with the total run time of 6 min with total solvent consumption of 2.4 mL per run. The method was found linear over the range 0.1-10 μg/mL with coefficient of determination R2 of 0.9997. The recovery was 98.09-100.19 %, and the method showed high precision and repeatability. Degradation pathway of gliclazide was studied following different types of stress degradation which are base, acid, UV, and oxidization. All validated parameters were in the acceptable range of ICH requirements. In conclusion, a new, rapid, sensitive, and economic method was developed and validated for the analysis of gliclazide in tablet dosage form. ? 2017, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

品名	編號(hào)
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 50 mm, 1/pkg	186006422
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 30 mm, 1/pkg	186006421
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 100 mm, 1/pkg	186006424
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 75 mm, 1/pkg	186006423
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 150 mm, 1/pkg	186006425
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 75 mm, 1/pkg	186006428
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 50 mm, 1/pkg	186004753
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 150 mm, 1/pkg	186006434
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 100 mm, 1/pkg	186006433
XSelect HSS C18 SB Column, 100?, 5 µm, 1 mm X 150 mm, 1/pkg	186006419
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 150 mm, 1/pkg	186004744
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 100 mm, 1/pkg	186004743
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 150 mm, 1/pkg	186004749
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 30 mm, 1/pkg	186004752
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 100 mm, 1/pkg	186004748
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 250 mm, 1/pkg	186004751
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 50 mm, 1/pkg	186004747
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 30 mm, 1/pkg	186004746
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 250 mm, 1/pkg	186006440
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 30 mm, 1/pkg	186006442
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 100 mm, 1/pkg	186006444
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 75 mm, 1/pkg	186006443
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 250 mm, 1/pkg	186004756
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 150 mm, 1/pkg	186004754
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 50 mm, 1/pkg	186004757
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 30 mm, 1/pkg	186006431
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 50 mm, 1/pkg	186006432
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 100 mm, 1/pkg	186006438
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 150 mm, 1/pkg	186006439
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 50 mm, 1/pkg	186006437