Anti- MUC4抗體說(shuō)明書(shū) antibody [8G-7]

Catalog Number :ab52263

Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )

Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Specificity : Anti-MUC4is a mouse monoclonal antibody

specific for MUC4of Human

use for western blotting,elisa,immunoprecipitation and immunohistochemistry

• Protein G affinity chromatography purification, purity :>95%
• Isotype: IgG
• mol wt: 239kDa
• Application :
• WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
• KLH conjugated synthetic peptide derived from human Muc4
• not yet tested in other applications.
• optimal dilutions/concentrations should be determined by the end user..

Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃

MUC4抗體說(shuō)明書(shū)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.MUC4抗體說(shuō)明書(shū)