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Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體

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公司名稱齊一生物科技（上海）有限公司
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更新時(shí)間2018/1/22 16:54:35
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Anti-Nogo-A 軸索過(guò)度生長(zhǎng)抑制因子-A抗體 Nogo A Foocen Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體

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Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體濃度 1mg/1ml
抗體來(lái)源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat,
產(chǎn)品類型一抗
研究領(lǐng)域細(xì)胞生物神經(jīng)生物學(xué)
蛋白分子量 predicted molecular weight: 131kDa
性狀 Lyophilized or Liquid

Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體產(chǎn)品信息

Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體相關(guān)標(biāo)記   Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5
Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC
英文名稱   Anti-Nogo-A
中文名稱   軸索過(guò)度生長(zhǎng)抑制因子-A抗體
別名   Nogo A; ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; Neurite growth inhibitor 220; Neurite Outgrowth Inhibitor; Neuroendocrine specific protein; Neuroendocrine specific protein C homolog; NI220/250; Nogo A; NOGO; Nogo protein; NogoA; NSP; NSP CL; Reticulon 4; Reticulon 5; Reticulon4; Reticulon5; RTN 4; RTN 4A; RTN X; RTN xL; RTN4 A; RTN4; RTN4 B1; RTN4 B2; RTN4 C; RTN4 protein; RTN4_HUMAN; Reticulon-4; Neuroendocrine-specific protein.
濃度   1mg/1ml
抗體來(lái)源   Rabbit
克隆類型   polyclonal
交叉反應(yīng)   Human, Mouse, Rat,
產(chǎn)品類型   一抗
研究領(lǐng)域   細(xì)胞生物神經(jīng)生物學(xué)
蛋白分子量   predicted molecular weight: 131kDa
性狀   Lyophilized or Liquid
免疫原   KLH conjugated synthetic peptide derived from human RTN4 protein
亞型   IgG
純化方法   affinity purified by Protein A
儲(chǔ) 存液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
Anti-Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A抗體產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件   Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note   This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹   This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Function : Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Subunit : Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1.
Subcellular Location : Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Tissue Specificity : Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
Similarity : Contains 1 reticulon domain.
Database links :
Entrez Gene: 57142 Human
Entrez Gene: 68585 Mouse
Entrez Gene: 83765 Rat
Omim: 604475 Human
SwissProt: Q9NQC3 Human
SwissProt: Q99P72 Mouse
SwissProt: Q9JK11 Rat
Unigene: 704007 Human

神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）
Nogo-A軸索生長(zhǎng)抑制因子在中樞神經(jīng)的髓鞘上表達(dá)并在抑制損傷軸索修復(fù)中起著關(guān)鍵作用，從而有限制神經(jīng)功能恢復(fù)的現(xiàn)象。主要定位細(xì)胞核。
產(chǎn)品圖片