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Anti-CD11b/c equivalent整合素αM抗體Integrin αM

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Anti-CD11b/c equivalent 整合素αM抗體Integrin αM Anti-CD11b/c equivalent整合素αM抗體Integrin αM Antigen CD11b （p170）

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Anti-CD11b/c equivalent整合素αM抗體Integrin αM抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Horse,
產(chǎn)品類型一抗
研究領(lǐng)域神經(jīng)生物學(xué) 細(xì)胞粘附分子
蛋白分子量 predicted molecular weight: 125kDa
性狀 Lyophilized or

Anti-CD11b/c equivalent整合素αM抗體Integrin αM 產(chǎn)品信息

Anti-CD11b/c equivalent整合素αM抗體Integrin αM抗體相關(guān)標(biāo)記   Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5
Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC
英文名稱   Anti-CD11b/c equivalent
中文名稱   整合素αM抗體Integrin αM
別名   Antigen CD11b (p170); CD11 antigen like family member B; CD11 antigen like family member C; CD11B; CD11C; Cell surface glycoprotein MAC 1 subunit alpha; CR 3 alpha chain; CR3A; Integrin alpha M; Integrin alpha X; Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; Leukocyte surface antigen p150,95, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor alpha M subunit; p150 95 integrin alpha chain; SLEB6; ITAM_HUMAN.
抗體來源   Rabbit
克隆類型   polyclonal
交叉反應(yīng)   Human, Mouse, Rat, Horse,
產(chǎn)品類型   一抗
研究領(lǐng)域   神經(jīng)生物學(xué) 細(xì)胞粘附分子
蛋白分子量   predicted molecular weight: 125kDa
性狀   Lyophilized or Liquid
免疫原   KLH conjugated synthetic peptide derived from human CD11b
亞型   IgG
純化方法   affinity purified by Protein A
儲存液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Anti-CD11b/c equivalent整合素αM抗體Integrin αM抗體產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-CD11b/c equivalent整合素αM抗體Integrin αM抗體產(chǎn)品介紹 CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue. CD11c is aiIntegrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Function : Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit : Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
Subcellular Location : Plasma membrane
Tissue Specificity : Predominantly expressed in monocytes and granulocytes.
DISEASE : Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity : Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
Database links : UniProtKB/Swiss-Prot: P11215.2