編 號(hào)：hy030424
名 稱(chēng)：Anti-MMP-1，基質(zhì)金屬蛋白酶1抗體
來(lái) 源：兔
交叉反應(yīng)：人、兔子、牛、狗等
Anti-MMP-1，基質(zhì)金屬蛋白酶1抗體克隆類(lèi)型：多克隆抗體
濃 度：1mg/1ml
性 狀：Lyophilized or Liquid
蛋白分子量：predicted molecular weight: 27/52kDa
應(yīng) 用：WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
備 注：本產(chǎn)品僅供科研實(shí)驗(yàn)使用。（This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications）
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The matrix metalloproteinases （MMPs） are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
Subunit : Interacts with HIV-1 Tat.
Subcellular Location : Secreted, extracellular space, extracellular matrix （Probable）.
Similarity : Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
